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KMID : 0352519860230030091
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Korea Univercity Medical Journal
1986 Volume.23 No. 3 p.91 ~ p.97
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Study on immunofluorescent antibodies against Hantaan, Seoul and Puumala viruses in sera from patients with hemorrhagic fever with renal syndrome in Korea
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Abstract
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Five patients with Hemorrhagic fever with renal syndrome who were caused by results of infection with Hantaan virus were bled at one week interval for two months and the sera were used for current study. Serum antibodies against Hantaan, Seoul and Puumala viruses were tested and compared by in-direct immunofluorescent antibody (IFA) technique.
The results are as follows:
1. Immunofluorescent (IF) antibodies against Hantaan virus were maximal about 2ti3 weeks after the onset of illness. Peak reciprocal IF antibody titers were 1,024-16,384. The titers of IF antibody against Seoul virus were lower in two folds than those of Hantaan virus.
2. IF antibodies against Puumala virus were remarkablely lower. Peak IF antibody titers were attained about 2ti3 weeks following the onset of illness and the reciprocal titer was 128 at the time.
3. IgM antibodies in the sera of patients were only detectable against Hantaan and Seoul viruses with same titers. Peak IF IgM antibody titers were attained about one week following the onset of illness and then decreased rapidly after three weeks.
This study conclude that infections with Hantaan and Seoul viruses were not differentiated by the demonstration of IgG antibody titers but infection with Puumala virus was easily differentiated. Also the demonstration of IgM antibody was the clue of recent infection of Hantaan or Seoul virus.
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